Antidiabetic Effects of IGFBP2, a Leptin-Regulated Gene
نویسندگان
چکیده
منابع مشابه
Leptin-regulated gene expression in MCF-7 breast cancer cells: mechanistic insights into leptin-regulated mammary tumor growth and progression.
Obesity is a recently established risk factor for breast cancer incidence and mortality. A characteristic of obesity is elevated circulating levels of adipocyte-derived hormone leptin. Evidence indicates that leptin plays an important role in mammary tumor formation; however, the mechanisms involved are poorly understood. Toward better defining the role of leptin in breast cancer, we describe t...
متن کاملDirect antidiabetic effect of leptin through triglyceride depletion of tissues.
Leptin is currently believed to control body composition largely, if not entirely, via hypothalamic receptors that regulate food intake and thermogenesis. Here we demonstrate direct extraneural effects of leptin to deplete fat content of both adipocytes and nonadipocytes to levels far below those of pairfed controls. In cultured pancreatic islets, leptin lowered triglyceride (TG) content by pre...
متن کاملAntidiabetic Effects of Tea.
Diabetes mellitus (DM) is a chronic endocrine disease resulted from insulin secretory defect or insulin resistance and it is a leading cause of death around the world. The care of DM patients consumes a huge budget due to the high frequency of consultations and long hospitalizations, making DM a serious threat to both human health and global economies. Tea contains abundant polyphenols and caff...
متن کاملAssociation of leptin gene (rs 7799039) polymorphism and colorectal cancer
Introduction: Studies show polymorphism in leptin gene cause increase in level of leptin hormone and increased level of leptin hormon is associated with abosity, insulin resistance and increased risk of colorectal cancer. The aim of this study was to assess the incidence of leptin gene polymorphism rs 7799039 in Tehran and to investigate the influence of this polymorphism in increased risk of c...
متن کاملEffects of growth hormone on leptin gene expression in rats.
RECENTLY the obesity gene was identified and its gene product, leptin, has demonstrated [1]. It is expressed exclusively in adipocytes, secreted into the blood stream and appears to signal to the hypothalamus through its specific receptor. It reduces appetite and stimulates energy expenditure. Thus it serves an endocrine function in body weight regulation of energy consumption and storage. Sinc...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Metabolism
سال: 2010
ISSN: 1550-4131
DOI: 10.1016/j.cmet.2010.02.010